Synthesis and biological evaluation of new benzo[ f ]furo[2,3‐ h ]‐and benzo[ f ]pyrano[2,3‐ h ]coumarin derivatives. | Zendy

Tsoukka Maria | Zendy; Litinas Konstantinos E. | Zendy; Nicolaides Demetrios N. | Zendy; HadjipavlouLitina Dimitra J. | Zendy

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Synthesis and biological evaluation of new benzo[ f ]furo[2,3‐ h ]‐and benzo[ f ]pyrano[2,3‐ h ]coumarin derivatives.

Author(s) -

Tsoukka Maria,

Litinas Konstantinos E.,

Nicolaides Demetrios N.,

HadjipavlouLitina Dimitra J.

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440304

Subject(s) - chemistry , furocoumarins , phosphorane , coumarin , toluene , radical , microwave irradiation , antioxidant , medicinal chemistry , furocoumarin , organic chemistry , stereochemistry , nuclear chemistry , photochemistry , biochemistry , catalysis , dna

Furocoumarins 3,5 and pyranocoumarin 7 were synthesized from the reaction of furonaphthalenediones 2,4 and pyranonaphthalenedione 6 respectively with carbethoxymethylene(triphenyl)phosphorane in refluxing DCM for 3‐6 hours or under microwave irradiation in toluene for a few minutes. Compounds 3,5,7 and their precursors were tested as anti‐inflammatory/antioxidant agents. They were found to compete significantly high DMSO for OH radicals, to scavenge O 2 − and to inhibit lipoxygenase to a high extent.

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