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Synthesis of 5,6,7,8‐tetrahydroindolizines via a domino‐type transformation based on the rhodium catalyzed hydroformylation of N ‐(β‐methallyl)pyrroles
Author(s) -
Rocchiccioli Silvia,
Guazzelli Giuditta,
Lazzaroni Raffaello,
Settambolo Roberta
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440234
Subject(s) - hydroformylation , chemistry , rhodium , domino , catalysis , potassium , transformation (genetics) , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , gene
Variously substituted 5,6,7,8‐tetrahydroindolizines can be easily synthesized via a domino reactions sequence under rhodium catalyzed hydroformylation of N ‐(β‐methallyl)pyrroles. The later are readily prepared from properly functionalized pyrroles via phase‐transfer N ‐allylation in the presence of 18‐crown‐6 and potassium tert ‐butoxide.