Synthesis of 5,6,7,8‐tetrahydroindolizines  via  a domino‐type transformation based on the rhodium catalyzed hydroformylation of  N ‐(β‐methallyl)pyrroles | Zendy

Rocchiccioli Silvia | Zendy; Guazzelli Giuditta | Zendy; Lazzaroni Raffaello | Zendy; Settambolo Roberta | Zendy

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Synthesis of 5,6,7,8‐tetrahydroindolizines via a domino‐type transformation based on the rhodium catalyzed hydroformylation of N ‐(β‐methallyl)pyrroles

Author(s) -

Rocchiccioli Silvia,

Guazzelli Giuditta,

Lazzaroni Raffaello,

Settambolo Roberta

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440234

Subject(s) - hydroformylation , chemistry , rhodium , domino , catalysis , potassium , transformation (genetics) , organic chemistry , combinatorial chemistry , medicinal chemistry , biochemistry , gene

Variously substituted 5,6,7,8‐tetrahydroindolizines can be easily synthesized via a domino reactions sequence under rhodium catalyzed hydroformylation of N ‐(β‐methallyl)pyrroles. The later are readily prepared from properly functionalized pyrroles via phase‐transfer N ‐allylation in the presence of 18‐crown‐6 and potassium tert ‐butoxide.

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