Biginelli‐like three component reaction: Synthesis of some new ethyl 6‐ethoxycarbonylmethyl‐4‐aryl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate derivatives | Zendy

Azizian Javad | Zendy; Mohammadi Ali A. | Zendy; Kohshari M. | Zendy; Karimi Ali R. | Zendy; Mohammadizadeh Mohammad R. | Zendy

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Biginelli‐like three component reaction: Synthesis of some new ethyl 6‐ethoxycarbonylmethyl‐4‐aryl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate derivatives

Author(s) -

Azizian Javad,

Mohammadi Ali A.,

Kohshari M.,

Karimi Ali R.,

Mohammadizadeh Mohammad R.

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440228

Subject(s) - chemistry , biginelli reaction , aldehyde , reactivity (psychology) , context (archaeology) , carboxylate , aryl , molecule , urea , organic chemistry , yield (engineering) , solvent , combinatorial chemistry , catalysis , medicine , paleontology , alkyl , alternative medicine , materials science , pathology , metallurgy , biology

In the context of our high‐throughput organic synthesis program, we have studied the reactivity of special β‐keto esters toward the Biginelli reaction. We have found that a diethyl‐3‐oxoglutarate reacts with one molecule of urea and one molecule of aldehyde under solvent‐free conditions to give a new family of 3,4‐dihydropyrimidin‐2(1 H )‐ones in good yields.

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