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Biginelli‐like three component reaction: Synthesis of some new ethyl 6‐ethoxycarbonylmethyl‐4‐aryl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate derivatives
Author(s) -
Azizian Javad,
Mohammadi Ali A.,
Kohshari M.,
Karimi Ali R.,
Mohammadizadeh Mohammad R.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440228
Subject(s) - chemistry , biginelli reaction , aldehyde , reactivity (psychology) , context (archaeology) , carboxylate , aryl , molecule , urea , organic chemistry , yield (engineering) , solvent , combinatorial chemistry , catalysis , medicine , paleontology , alkyl , alternative medicine , materials science , pathology , metallurgy , biology
In the context of our high‐throughput organic synthesis program, we have studied the reactivity of special β‐keto esters toward the Biginelli reaction. We have found that a diethyl‐3‐oxoglutarate reacts with one molecule of urea and one molecule of aldehyde under solvent‐free conditions to give a new family of 3,4‐dihydropyrimidin‐2(1 H )‐ones in good yields.