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Synthesis of 2,2′‐bipyridyl‐type compounds via the suzuki‐miyaura cross‐coupling reaction
Author(s) -
Jones Nicholas A.,
Antoon James W.,
Bowie Alfred L.,
Borak J. Brian,
Stevens Erland P.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440213
Subject(s) - chemistry , halogen , coupling reaction , coupling (piping) , ring (chemistry) , substitution (logic) , combinatorial chemistry , halide , organic chemistry , polymer chemistry , medicinal chemistry , catalysis , mechanical engineering , alkyl , computer science , engineering , programming language
Abstract2,2′‐Bipyridyl‐type compounds may be prepared by Suzuki‐Miyaura coupling of a 2‐pyridylboronic ester with 2‐haloazines and ‐azoles. Ten examples are presented with yields of 47 to 84%. Both arylbromides and arylchlorides undergo the coupling, but the reaction is sensitive to ring substitution adjacent to the halogen.