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Synthesis of a new series of pyrazolo[1,5‐ a ]pyrimidines structurally related to zaleplon
Author(s) -
Baraldi Pier Giovanni,
Fruttarolo Francesca,
Tabrizi Mojgan Aghazadeh,
Romagnoli Romeo,
Preti Delia,
Ongini Ennio,
ElKashef Hussein,
Carrión María Dora,
Borea Pier Andrea
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440212
Subject(s) - chemistry , bicyclic molecule , pyrazole , stereochemistry , series (stratigraphy) , paleontology , biology
The reaction between 3‐(dimethylamino)/3,3‐bis(methylthio)‐1‐(substituted)prop‐2‐en‐1‐ones and 4‐substituted‐5‐amino‐1 H ‐pyrazoles afforded new pyrazole[1,5‐ a ]pyrimidines structurally related to Zaleplon. The chemical modifications introduced at the 3‐, 5‐, and 7‐positions of the bicyclic structure revealed new promising candidates for the treatment of sleep disorders.