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Synthesis of 5‐[(4‐phenylpiperazin‐1‐yl)methyl]pyrrolo‐[2,3‐ d ]pyrimidine derivatives as potential dopamine D4 receptor ligands
Author(s) -
Linz Sabine,
Troschütz Reinhard
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440211
Subject(s) - chemistry , pyrimidine , pyrrole , dopamine , mannich reaction , formaldehyde , amine gas treating , stereochemistry , organic chemistry , catalysis , neuroscience , biology
A series of pyrrolo[2,3‐ d ]pyrimidine Mannich bases of type 9, 12, 15 and 16 have been prepared as potential dopamine D4 receptor ligands. The syntheses start from 4‐aminopyrimidin‐6‐one 3 with pyrrole annulations and Mannich reactions with formaldehyde and phenylpiperazines 8 as new amine components.