Substituted quinolinones. Part 13 a convenient route to heterocyclization reactions with 3‐substituted 4‐hydroxyquinolin‐2(1 H )‐one | Zendy

AbdelMegid Mohamed | Zendy; Abass Mohamed | Zendy; Hassan Mohamed | Zendy

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Substituted quinolinones. Part 13 a convenient route to heterocyclization reactions with 3‐substituted 4‐hydroxyquinolin‐2(1 H )‐one

Author(s) -

AbdelMegid Mohamed,

Abass Mohamed,

Hassan Mohamed

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440206

Subject(s) - chemistry , reagent , electrophile , nucleophile , reactivity (psychology) , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology

The reactivity of 3‐[(dimethylamino)prop‐2‐enoyl]‐4‐hydroxyl‐1‐methylquinolin‐2(1 H )‐one ( 2 ) towards different nucleophilic and electrophilic reagents was investigated. The convenient synthesis of several 3‐heterocyclyl‐quinolinones such as 3‐pyridazinyl‐ 10, 11 , 3‐pyranyl 19a,b and 3‐pyrazolylquinolinones 20a,b, 22, 26a,b, 27a,b, 31 and 33 has been described starting from the 3‐acetylquinolinone 1 and enaminone 2 . In addition, certain heterocyclo[ c ]quinolinones such as pyrimido‐ 12, 14 pyrano‐ 3, 17a,b and pyrazolopyranoquinolinone 29 were obtained in good yields.

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