Novel compounds for the synthesis of cefdinir | Zendy

Rao K. V. V. Prasada | Zendy; Dandala Ramesh | Zendy; Sivakumaran Meenakshisunderam | Zendy; Rani Ananta | Zendy; Naidu A. | Zendy

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Novel compounds for the synthesis of cefdinir

Author(s) -

Rao K. V. V. Prasada,

Dandala Ramesh,

Sivakumaran Meenakshisunderam,

Rani Ananta,

Naidu A.

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440205

Subject(s) - chemistry , cefdinir , high performance liquid chromatography , amino acid , carboxylic acid , medicinal chemistry , stereochemistry , organic chemistry , cephalosporin , biochemistry , antibiotics

Preparation of two new compounds 2‐mercapto‐5‐methyl‐1,3,4‐thiadiazolyl‐(Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐trityloxyiminoacetate ( 14 ) and 2‐mercapto‐5‐methyl‐1, 3,4‐thiadiazolyl‐ (Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐acetyloxyiminoacetate ( 12 ) and their use in the preparation of 7β‐[(Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐hydroxyiminoacetamido]‐3‐vinylcephem‐4‐carboxylic acid, also known by the generic name Cefdinir ( 1 ) has been accomplished in a single step by coupling with 7‐amino‐3‐vinylcephem‐4‐carboxylic acid ( 7 ) with purity of greater than 99% by HPLC.

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