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Novel compounds for the synthesis of cefdinir
Author(s) -
Rao K. V. V. Prasada,
Dandala Ramesh,
Sivakumaran Meenakshisunderam,
Rani Ananta,
Naidu A.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440205
Subject(s) - chemistry , cefdinir , high performance liquid chromatography , amino acid , carboxylic acid , medicinal chemistry , stereochemistry , organic chemistry , cephalosporin , biochemistry , antibiotics
Preparation of two new compounds 2‐mercapto‐5‐methyl‐1,3,4‐thiadiazolyl‐(Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐trityloxyiminoacetate ( 14 ) and 2‐mercapto‐5‐methyl‐1, 3,4‐thiadiazolyl‐ (Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐acetyloxyiminoacetate ( 12 ) and their use in the preparation of 7β‐[(Z)‐2‐(2‐amino‐4‐thiazolyl)‐2‐hydroxyiminoacetamido]‐3‐vinylcephem‐4‐carboxylic acid, also known by the generic name Cefdinir ( 1 ) has been accomplished in a single step by coupling with 7‐amino‐3‐vinylcephem‐4‐carboxylic acid ( 7 ) with purity of greater than 99% by HPLC.