Preparation of 5‐methyl‐2‐sulfanyl‐7 h ‐1,3,4‐thiadiazolo[3,2‐ a ]‐pyrimidin‐7‐ones | Zendy

Safarov Saifidin | Zendy; Kukaniev Muhamacho A. | Zendy; Karpuk Elena | Zendy; Meier Herbert | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Preparation of 5‐methyl‐2‐sulfanyl‐7 h ‐1,3,4‐thiadiazolo[3,2‐ a ]‐pyrimidin‐7‐ones

Author(s) -

Safarov Saifidin,

Kukaniev Muhamacho A.,

Karpuk Elena,

Meier Herbert

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440145

Subject(s) - chemistry , diketene , sulfanyl , ring (chemistry) , nucleophilic substitution , acylation , nucleophile , medicinal chemistry , dehydration , thiadiazoles , stereochemistry , organic chemistry , catalysis , biochemistry

7 H ‐1,3,4‐Thiadiazolo[3,2‐ a ]pyrimidin‐7‐ones can be prepared by the acylation of 5‐amino‐1,3,4‐thiadiazoles with diketene and subsequent ring closure (dehydration). Whereas arylthio substituents (SC 6 H 5 ) can be introduced in 2‐position by the replacement of Br, alkylthio groups (SC 2 H 5 ) have to be already presentin the starting 5‐amino‐1,3,4‐thiadiazole. The ambident nucleophile 2‐thiazolidinethione reacts in the Br substitution reaction on the N atom.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research