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Flash vacuum pyrolysis of 1‐azolyl‐1‐phenylhydrazono‐2‐propanones
Author(s) -
ElDusouqui Osman M. E.,
Dib Hicham H.,
AlAwadi Nouria A.,
Abdelkhalik Mervat M.,
AlEtaibi Alya M.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440135
Subject(s) - chemistry , flash vacuum pyrolysis , cinnoline , acetone , pyrolysis , medicinal chemistry , flash (photography) , stereochemistry , organic chemistry , art , visual arts
Flash vacuum pyrolysis (FVP) of 1‐(2‐arylhydrazono)‐1‐(1 H ‐1,2,4‐triazol‐1‐yl)acetone 8a‐c at 650 °C and 2.67 Pa yielded 5‐substituted 1‐(1 H ‐indazol‐3‐yl)ethanone 14a‐c and 4,6‐disubstituted cinnoline 18a‐c . Similarly FVP of 1‐(1 H ‐benzo[ d ]imidazol‐1‐yl)‐1‐(2‐phenylhydrazono)acetone 9a‐c gave 8 H ‐benzo[4′,5′]imidazo[2′,1′:5,1]pyrrolo[2,3‐ c ]cinnoline derivatives 23a‐c . A plausible mechanism is suggested to account for their transformation based on the kinetics and products of reaction.