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An efficient and high yielding protocol for the synthesis of substituted dihydropyrimidin‐2(1 h )‐ones and spiro‐fused heterocycles by involving tandem reactions
Author(s) -
Bose D Subhas,
Idrees MohD.
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440133
Subject(s) - chemistry , aldehyde , catalysis , tandem , combinatorial chemistry , urea , alkyl , medicinal chemistry , organic chemistry , materials science , composite material
A simple and efficient method has been developed for the synthesis of 3,4‐dihydropyrimidin‐2(1 H )‐ones by a one‐pot three component cyclocondensation reaction of alkyl acetoacetates, aldehyde, and urea in the presence of a catalytic amount of the reusable catalyst zinc per chlorate hexahydrate, Zn(ClO 4 ) 2 .6H 2 O (10 mol %) the scope of this protocol is utilized for the synthesis of mitotic Kinesin EG5 inhibitor monastrol and new class of fused heterobicyclic compounds in high yields.