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Studies with azoles and benzoazoles: A novel simple approach for synthesis of 3‐functionally substituted 3‐acylindoles
Author(s) -
AbdelMotaleb Ramadan Maawad,
Makhloof AbdelMoneim AbdelSalam,
Ibrahim Hamada Mohamed,
Elnagdi Mohamed Hilmy
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440119
Subject(s) - chemistry , chloroacetyl chloride , acetic anhydride , yield (engineering) , indole test , combinatorial chemistry , chloride , acetyl chloride , organic chemistry , catalysis , materials science , metallurgy
3‐Substituted acylindoles 8 are obtained via refluxing carboxylic acids with indole in acetic anhydride solutions. The formed 3‐substituted acylindole 8a is readily converted into 4‐aminopyrazol‐3‐ylindoles 20 , and into 22 . Indole reacts with chloroacetyl chloride to yield: 3‐chloroacetylindole 9 which could also be utilized for synthesis of a number of 3‐substituted indoles.
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