A novel synthesis of some new benzoyl‐substituted heterocycles from 2‐benzoyl‐3‐phenylpent‐2‐ene‐1,5‐dinitrile | Zendy

Abdelrazek Fathy M. | Zendy; Ghozlan Said A. | Zendy; Michael Farid A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A novel synthesis of some new benzoyl‐substituted heterocycles from 2‐benzoyl‐3‐phenylpent‐2‐ene‐1,5‐dinitrile

Author(s) -

Abdelrazek Fathy M.,

Ghozlan Said A.,

Michael Farid A.

Publication year - 2007

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570440110

Subject(s) - chemistry , cyanoacetamide , pyridazine , halogenation , medicinal chemistry , derivative (finance) , benzoyl chloride , thiophene , pyridine , ene reaction , hydrogen sulfide , organic chemistry , sulfur , financial economics , economics

2‐Benzoyl‐3‐phenylpent‐2‐ene‐1,5‐dinitrile 1 undergoes bromination with N ‐bromosuccinimide (NBS) to afford the bromo derivative 2a . This bromo derivative undergoes reactions with sodium hydrogen sulfide, ethyl thioglycollate, hydroxylamine hydrochloride, hydrazines, cyanoacetamide, cyanacetohydrazide and urea derivatives to afford the thiophene 4 , 4 H ‐thiopyran 6 , 4 H ‐1,2‐oxazine 8 , 4 H ‐pyridazines 10a,b , the pyridine 15 , pyrrolo[1,2‐ b ]pyridazine 17 and the N‐substituted‐pyrrole derivatives 19a‐c respectively.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research