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A novel synthesis of some 2‐imino‐4‐thiazolidinone derivatives
Author(s) -
Moghaddam Firouz Matloubi,
Hojabri Leila
Publication year - 2007
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570440106
Subject(s) - chemistry , isothiocyanate , phenyl isothiocyanate , nucleophilic substitution , amide , sulfur , chlorine atom , base (topology) , nucleophile , chlorine , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , mathematical analysis , mathematics
An efficient and simple route is presented to the synthesis of some iminothiazolidinone derivatives. α‐Chloro amide derivatives undergo coupling reaction with isothiocyanate in the presence of a mild base, followed by nucleophilic substitution of chlorine by the sulfur atom of isothiocyanate.