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A general synthesis of 8‐hydroxy‐6‐substituted‐1,7‐naphthyridines
Author(s) -
Jiang Xinglong,
Chen GuangPei,
Prasad Kapa,
Repič Oljan,
Blacklock Thomas J.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430648
Subject(s) - chemistry , acylation , ammonium acetate , ammonium , organic chemistry , combinatorial chemistry , medicinal chemistry , high performance liquid chromatography , catalysis
A general method for the synthesis of 8‐hydroxy‐6‐substituted‐1,7‐naphthyridines is described using acylation of the dianion derived from tert ‐butylamide 1 , followed by cyclization of the resulting intermediate ketones 2 with ammonium acetate.
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