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The [3 + 2] cycloaddition route to 5‐carbomethoxy‐4 h ‐1,2,3‐triazolo[1,5‐ a ][1]benzazepines from baylis‐hillman acetates of 2‐azidobenzaldehydes
Author(s) -
Song Young Seok,
Lee KeeJung
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430647
Subject(s) - benzazepines , chemistry , cycloaddition , reagent , stereochemistry , medicinal chemistry , organic chemistry , catalysis
A new, simple synthesis of 5‐carbomethoxy‐4 H ‐1,2,3‐triazolo[1,5‐ a ][1]benzazepines from the reaction of several Baylis‐Hillman acetates of 2‐azidobenzaldehydes with alkynide Grignard reagents such as phenylethynyl‐, 1‐propynyl‐ and ethynylmagnesium bromides followed by cycloaddition reaction has been described.