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First synthesis of furo[3,4‐ c ]coumarins
Author(s) -
Brahmbhatt Dinker I.,
Gajera Jitendra M.,
Patel Chirag N.,
Pandya Vishwesh P.,
Pandya Urvish R.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430643
Subject(s) - chemistry , demethylation , aryl , ethyl acetoacetate , nitro , medicinal chemistry , organic chemistry , stereochemistry , catalysis , biochemistry , gene expression , alkyl , dna methylation , gene
Various 1,3‐dimethyl and 1‐methyl‐3‐phenylfuro[3,4‐ c ]coumarins ( 5a‐h and 6a‐h ) have been synthesized by demethylation cyclization of the respective 3‐aryl‐4‐ethoxycarbonyl furans ( 3a‐h and 4a‐h ). These ethoxycarbonyl furans were prepared by reacting appropriate 1‐aryl‐2‐nitro‐prop‐1‐ene ( 1a‐h ) with ethyl acetoacetate or ethyl benzoylacetate under Nef reaction condition.