Premium
Microwave‐assisted “green” synthesis of 2‐alkyl/arylbenzothiazoles in one pot: A facile approach to anti‐tumor drugs
Author(s) -
Kamila Sukanta,
Koh Benjamin,
Biehl Edward R.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430627
Subject(s) - chemistry , benzothiazole , alkyl , aryl , carbon 13 nmr , elemental analysis , proton nmr , microwave irradiation , organic chemistry , combinatorial chemistry , catalysis
A series of new 2‐alkyl/arylbenzothiazoles has been synthesized on the basis of the potent and selective in vitro anti‐tumor properties of 2‐(3,4‐diethoxyphenyl)‐5‐fluorobenzothiazole. The synthesis of benzothiazole analogs was achieved via microwave irradiation of a 1:1 mixture of o ‐aminothiophenol and alkyl/aryl acylacetonitriles at temperature of 200°C for 10 min. The yields are very good to excellent. All the products were characterized by 1 H nmr, 13 C nmr and elemental analysis.