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Synthetic studies connected with the preparation of h + /k + ‐ATPase inhibitors rabeprazole and lansoprazole
Author(s) -
Rédl Stanislav,
Klecén Ondřej,
Havlíček Jaroslav
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430606
Subject(s) - chemistry , lansoprazole , rabeprazole , stereochemistry , medicinal chemistry , biochemistry , gastroenterology , medicine , proton pump inhibitor , helicobacter pylori
ynthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2‐[(4‐nitro‐3‐methylpyridin‐2‐yl)methanesulfanyl]‐1 H ‐benzoimidazole and 2‐[(4‐chloro‐3‐methyl‐pyridin‐2‐yl)methanesulfanyl]‐1 H ‐benzoimidazole, were prepared in several ways.
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