Synthesis of novel quinazoline non‐nucleosides analogues of the HIV drug emivirine | Zendy

ElBrollosy Nasser R. | Zendy

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Synthesis of novel quinazoline non‐nucleosides analogues of the HIV drug emivirine

Author(s) -

ElBrollosy Nasser R.

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430604

Subject(s) - chemistry , quinazoline , drug , combinatorial chemistry , human immunodeficiency virus (hiv) , stereochemistry , pharmacology , virology , biology , medicine

Novel quinazoline non‐nucleosides analogues of Emivirine were described. Compounds 1a‐c were silylated and reacted with the appropriate chloroethers ( 2a‐c ) in the presence of CsI to give the corresponding non‐nucleosides 3a‐h and 4a‐h . Silylation of 1a‐c and treatment with bis(allyloxy)methanes ( 5a,b ) afforded the corresponding 1‐(allyloxymethyl)quinazolines 6a‐f. 1‐(Propargyloxymethyl)‐quinazolines 8a,b were obtained by treatment of the silylated 1a,b with bis(propargyloxy)methane ( 7 ) in the presence of TMS triflate.

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