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Isonicotinoylhydrazothiazoles and isonicotinoyl‐N 4 ‐substituted thiosemicarbazides: Synthesis, characterization, and anti‐mycobacterial activity
Author(s) -
Cardia Maria Cristina,
Distinto Simona,
Maccioni Elias,
Plumitallo Antonio,
Sanna Maria Luisa,
Saddi Manuela,
Delogu Alessandro
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430529
Subject(s) - chemistry , antimycobacterial , elemental analysis , mass spectrometry , carbon 13 nmr , proton nmr , nuclear chemistry , stereochemistry , organic chemistry , mycobacterium tuberculosis , chromatography , tuberculosis , medicine , pathology
Differently substituted isonicotinoylhydrazothiazoles and isonicotinoyl‐N 4 ‐substituted thiosemi‐carbazides have been prepared and characterized by means of elemental analysis, 1 H‐NMR, 13 C‐NMR, and Mass spectrometry. All the synthesised compounds have been screened in order to evaluate their antimycobacterial activity in vitro. Some of the new compounds showed activity towards M. tuberculosis H37R and M. Marinum in the millimolar range.