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New access to thiazolo[4,5‐ d ]pyrimidine derivativess
Author(s) -
Bakavoli M.,
Nikpour M.,
Rahimizadeh M.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430527
Subject(s) - chemistry , pyrimidine , ammonia , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry
4‐Amino‐5‐bromo‐2‐substituted‐aminopyrimidines are readily obtained from the newly prepared 5‐bromo‐2,4‐dichloro‐6‐methylpyrimidine by sequential treatment with ethanolic ammonia and secondary amines. These compounds were successfully reacted with various isothiocyanates in the presence of sodamide in DMF to form the new thiazolo[4,5‐ d ] pyrimidine derivatives.