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Synthesis of first representatives of 3,3′‐bi(6,8‐dialkyl‐2,4‐dioxa‐6,8‐diazabicyclo[3.3.0]octan‐7‐ones)
Author(s) -
Sigachev Andrey S.,
Kravchenko Angeli.,
Gazieva Galina A.,
Belyakov Pavel A.,
Kolotyrkital'Ya G.,
Lebedev Oleg V.,
Makhova Ni.,
Lyssenko Konstantin A.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430523
Subject(s) - chemistry , glyoxal , stereochemistry , medicinal chemistry , organic chemistry
The first representatives of 3,3′‐bi(2,4‐dioxa‐6,8‐diazabicyclo[3.3.0]octan‐7‐ones) have been synthesized by a reaction of glyoxal as form of 2,2′‐bi(4,5‐dihydroxy‐1,3‐dioxalane) with N,N′‐dialkylureas. Their structures have been supported by X‐ray analysis. 1,3‐Dialkylimidazolidine‐2,4‐diones (hydantoins) have been isolated as by‐products and their formation mechanism has been experimentally confirmed.