Cyclization of 2‐benzoylamino‐ N ‐methyl‐thiobenzamides to 3‐methyl‐2‐phenylquinazolin‐4‐thiones | Zendy

Hanusek Jiří | Zendy; Drabina Pavel | Zendy; Sedlák MiloŠ | Zendy; Rosa Pavel | Zendy

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Cyclization of 2‐benzoylamino‐ N ‐methyl‐thiobenzamides to 3‐methyl‐2‐phenylquinazolin‐4‐thiones

Author(s) -

Hanusek Jiří,

Drabina Pavel,

Sedlák MiloŠ,

Rosa Pavel

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430521

Subject(s) - chemistry , sodium methoxide , acylation , medicinal chemistry , methoxide , sodium , sodium salt , ring (chemistry) , kinetics , nuclear magnetic resonance spectroscopy , catalysis , organic chemistry , inorganic chemistry , physics , quantum mechanics

Acylation of 2‐amino‐ N ‐methyl‐thiobenzamide with substituted benzoyl chlorides has been used to synthesize the corresponding 2‐benzoylamino‐ N ‐methylthiobenzamides. Subsequent sodium methoxide‐catalyzed ring closure gives the corresponding 3‐methyl‐2‐phenylquinazoline‐4‐thiones. These compounds were characterized by means of their 1 H‐ and 12 C‐NMR spectra. The kinetics of the cyclization reaction has been followed with UV‐VIS spectroscopy at 100 °C in methanolic solutions of sodium methoxide.

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