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Synthesis and evaluation of condensed and noncondensed heterocyclic compounds of industrial application
Author(s) -
Eissa A. M. F.,
ElSayed R.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430505
Subject(s) - chemistry , anthranilic acid , formamide , propylene oxide , nucleophile , hydrazine (antidepressant) , organic chemistry , hydrate , antimicrobial , cloud point , ethylene oxide , cyanuric chloride , combinatorial chemistry , catalysis , chromatography , extraction (chemistry) , polymer , copolymer
The reaction of 2‐hydroxyoctadecanoyl chloride ( 2 ) and anthranilic acid gave 2‐(1‐hydroxyheptadecyl)‐4 H ‐3,1‐benzoxazin‐4‐one ( 3 ) which was used as starting material to synthesize some condensed and noncondensed heterocyclic compounds by reaction with nitrogen nucleophiles ( e.g. , hydrazine hydrate, and formamide). Subsequent reaction of the synthetic products with different amounts of propylene oxide gave a novel group of nonionic compounds having a double function as antimicrobial and surface active agents which may be useful in the manufacture of drugs, cosmetics, pesticides or as antibacterial and/or antifungal. The surface active properties such as surface and interfacial tensions, cloud point, foaming height, wetting time, and emulsification power were determined. The antimicrobial and biodegradability were also screened.