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Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3‐amino‐2‐thioxo‐2,3‐dihydrothieno[2,3‐ d ]pyrimidin‐4(1 H )‐ones, potential cox‐2 selective inhibitors
Author(s) -
Granata Giuseppe,
Barbagallo Salvatore,
Perdicaro Antonio,
Marrazzo Agostino,
Santagati Andrea,
Lombardo Laura,
Cardile Venera
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430443
Subject(s) - chemistry , sulfonamide , in vitro , stereochemistry , medicinal chemistry , combinatorial chemistry , biochemistry
Methane sulfonamide derivatives of 3‐amino‐2‐thioxo‐2,3‐dihydrothieno[2,3‐ d ]pyimidin‐4(1 H )‐one, potential selective COX‐2 inhibitors, were synthesized and their structural elucidation is here reported. Some derivatives, at 10 μM concentration, showed a significant percentage of inhibition in some in vitro experiments.