Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3‐amino‐2‐thioxo‐2,3‐dihydrothieno[2,3‐ d ]pyrimidin‐4(1 H )‐ones, potential cox‐2 selective inhibitors | Zendy

Granata Giuseppe | Zendy; Barbagallo Salvatore | Zendy; Perdicaro Antonio | Zendy; Marrazzo Agostino | Zendy; Santagati Andrea | Zendy; Lombardo Laura | Zendy; Cardile Venera | Zendy

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Synthetic approaches to bridgehead nitrogen methanesulfonamide derivatives of 3‐amino‐2‐thioxo‐2,3‐dihydrothieno[2,3‐ d ]pyrimidin‐4(1 H )‐ones, potential cox‐2 selective inhibitors

Author(s) -

Granata Giuseppe,

Barbagallo Salvatore,

Perdicaro Antonio,

Marrazzo Agostino,

Santagati Andrea,

Lombardo Laura,

Cardile Venera

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430443

Subject(s) - chemistry , sulfonamide , in vitro , stereochemistry , medicinal chemistry , combinatorial chemistry , biochemistry

Methane sulfonamide derivatives of 3‐amino‐2‐thioxo‐2,3‐dihydrothieno[2,3‐ d ]pyimidin‐4(1 H )‐one, potential selective COX‐2 inhibitors, were synthesized and their structural elucidation is here reported. Some derivatives, at 10 μM concentration, showed a significant percentage of inhibition in some in vitro experiments.

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