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Microbial screening of novel synthesized formazans having amide linkagesΦ
Author(s) -
Desai Krunal G.,
Desai Kishor R.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430440
Subject(s) - chemistry , schiff base , bacillus subtilis , candida albicans , candida krusei , amide , candida parapsilosis , staphylococcus aureus , antibacterial activity , stereochemistry , organic chemistry , bacteria , microbiology and biotechnology , candida tropicalis , biochemistry , yeast , genetics , biology
Formazans 5(a‐j) have been prepared by the condensation between schiff base 3 and diazonium salt of substituted 2‐amino benzothiazole 4(a‐j) . The intermediate schiff base 3 was synthesized by the condensation of p ‐nitrobenzolyhydrazide 1 with thiophene‐2‐aldehyde 2 . All the compounds have been screened for their antifungal activity against Candida albicans (ATCC ‐64550), Candida krusei (ATCC‐14243) and Candida parapsilosis (ATCC‐22019) and antibacterial activity against Escherchia coli (ATCC‐6538), Staphylococcus aureus (ATCC‐6538), Pseudomonas aeruginosa (ATCC‐1539) and Bacillus substilis (ATCC‐6633) . The structures of the synthesised compounds 5(a‐j) have been characterized on the basis of their elemental analysis and spectral data (UV, IR, 1 H NMR, 13 C NMR and Mass).