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Synthesis and biological activities of cis and trans 5‐amino‐3‐[(6‐chloro‐3‐pyridyl)methyl]amino‐1‐(5,5‐dimethyl‐2‐oxo‐4‐substitutedphenyl‐1,3,2‐dioxaphosphinan‐2‐yl)‐4‐cyano(ethoxycarbonyl)‐1 H ‐pyrazoles
Author(s) -
Luo ZaiGang,
Shi DeQing
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430430
Subject(s) - chemistry , bioassay , elemental analysis , nuclear magnetic resonance spectroscopy , cis–trans isomerism , single crystal , stereochemistry , crystal structure , proton nmr , spectroscopy , medicinal chemistry , organic chemistry , crystallography , genetics , physics , quantum mechanics , biology
A series of novel title compounds have been designed and synthesized by a multi‐step reaction, the stereochemistry of the reaction was investigated, the structures of all compounds prepared have been confirmed by 1 H NMR, IR, EI‐MS spectroscopy and elemental analysis. The crystal structures of cis 6b and trans 6b were determined by single crystal X‐ray diffraction. The results of preliminary bioassay indicate that some compounds possess a certain extent inhibition effect against aphides at the concentration of 250 ppm.