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Synthesis and biological activity of novel 1‐(2,3,4‐trimethoxyphenyl)‐2‐{[5‐(3,4,5‐trimethoxyphenyl)‐1,3,4‐thiadiazol‐2‐yl]thio}ethanone oxime ester derivatives
Author(s) -
Xue Wei,
Song Baoan,
He Wei,
Wang Hua,
Yang Song,
Jin Linhong,
Hu Deyu,
Liu Gang,
Lu Ping
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430409
Subject(s) - chemistry , thio , oxime , yield (engineering) , bioassay , proton nmr , gallic acid , carbon 13 nmr , stereochemistry , biological activity , spectral analysis , in vitro , organic chemistry , combinatorial chemistry , medicinal chemistry , antioxidant , biochemistry , spectroscopy , materials science , biology , metallurgy , genetics , physics , quantum mechanics
In a search for new fungicide and anticancer agent with improved biological properties and different bioactivity spectrum, we designed and synthesized a series of novel oxime esters containing 1,3,4‐thiadiazole group in moderate yield starting from gallic acid. The title compounds were identified by IR, 1 H NMR, 13 C NMR and elemental analysis. The bioassay tests showed that these title compounds exhibit weak to moderate anticancer activity in vitro by MTT method.