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An efficient one‐pot synthesis of 5‐aryl substituted 2‐amino‐5,8‐dihydropyrido[2,3‐ D ] pyrimidin‐4,7‐diones under microwave irradiationl without catalyst
Author(s) -
Tu Shujiang,
Wang Qian,
Xu Jianing,
Zhu Xiaotong,
Zhang Jinpeng,
Jiang Bo,
Jia Runhong,
Zhang Yan,
Zhang Junyong
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430407
Subject(s) - chemistry , catalysis , aldehyde , yield (engineering) , aryl , microwave irradiation , condensation , microwave , environmentally friendly , organic chemistry , condensation reaction , combinatorial chemistry , ecology , materials science , alkyl , physics , quantum mechanics , biology , metallurgy , thermodynamics
A series of 5‐aryl substituted 2‐amino‐5,8‐dihydropyrido[2,3‐ d ]pyrimidin‐4,7‐diones were synthesized through one‐pot condensation of 2,6‐diaminopyrimidin‐4‐one, aldehyde and Meldrum's acid using glycol as energy transfer agent under microwave irradiation without catalyst. The one‐pot protocol in the absence of catalyst has the advantage of good yield (86‐95%), short route and reaction time (3‐6 min) and environmentally friendly.