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Ruthenium‐catalyzed biginelli condensation: A simple and efficient one‐pot synthesis of 3,4‐dihydropyrimidin‐2(1 H )‐ones under mild reaction conditions
Author(s) -
Jain Suman L.,
Sharma Vishal B.,
Sain Bir
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430339
Subject(s) - chemistry , aldehyde , ruthenium , catalysis , urea , condensation , biginelli reaction , condensation reaction , reaction conditions , organic chemistry , combinatorial chemistry , physics , thermodynamics
Ruthenium trichloride was found to be an efficient catalyst for the first time for the synthesis of a variety of 3,4‐dihydropyrimidin‐2(1 H )‐ones by cyclocondensation of an aldehyde, β‐dicarbonyl compound and urea in excellent yields under mild reaction conditions.