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An efficient synthesis of benzo[ b ][1,8]naphthyridine‐3‐carboxylic methyl esters
Author(s) -
Nithyadevi V.,
Rajendran S. P.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430334
Subject(s) - chemistry , reagent , acetonitrile , amine gas treating , medicinal chemistry , carboxylate , stereochemistry , organic chemistry
Methyl‐3‐(2‐chloroquinolin‐3‐yl)acrylates 5a‐i on reaction with methyl amine in acetonitrile yielded methyl‐3‐[2‐(methylamino)quinolin‐3‐yl]acrylates 6a‐i . When, these were followed by the reaction with the Vilsmeier reagent, they afforded methyl benzo[ b ][1,8]naphthyridin‐3‐carboxylate 7a‐i in good yields.