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Δ 2 ‐Isoxazolines from β,γ‐unsaturated oximes
Author(s) -
Mosher Michael D.,
Emmerich Laura G.,
Frost Katherine S.,
Anderson Benjamin
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430303
Subject(s) - chemistry , organic chemistry , palladium , combinatorial chemistry , catalysis
3,5‐Disubstituted Δ 2 ‐isoxazolines can be prepared using the palladium‐mediated nucleometalation / methoxycarbonylation of β,γ‐unsaturated oximes. This novel route to this class of compounds is tolerant of a wide variety of functionality in the starting material, and provides a rapid route to highly functionalized isoxazolines.
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