Reactivity of 3‐amino‐3 H ‐quinazolin‐4‐one derivatives towards some electrophilic and nucleophilic reagents and using of the products in the building of some interesting heterocycles as anticancer agent | Zendy

AbdelRahman Taha.M. | Zendy

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Reactivity of 3‐amino‐3 H ‐quinazolin‐4‐one derivatives towards some electrophilic and nucleophilic reagents and using of the products in the building of some interesting heterocycles as anticancer agent

Author(s) -

AbdelRahman Taha.M.

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430302

Subject(s) - chemistry , electrophile , nucleophile , reactivity (psychology) , benzamide , reagent , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , medicine , alternative medicine , pathology , catalysis

The chemical reactivity of N ‐[1‐(3‐amino‐6,8‐dibromo‐4‐oxo‐3,4‐dihydro‐quinazolin‐2‐yl)‐2‐(2‐chlorophenyl)‐vinyl]benzamide ( 3 ) towards electrophilic and nucleophilic reagents have been reported. Structures of the products 3‐24 have been confirmed by elemental analysis and spectral data (IR, 1 H‐NMR, 13 C and MS). The bioassay indicates that some of the prepared compounds have a good selective anticancer activity.

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