Premium
The synthesis and evaluation of some coumarin derivatives as fluorescent indicators of nitroreductase activity
Author(s) -
James Arthur L.,
Perry John D.,
Stanforth Stephen P.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430241
Subject(s) - chemistry , nitroreductase , coumarin , fluorescence , carbamate , combinatorial chemistry , organic chemistry , enzyme , physics , quantum mechanics
The carbamate 8 was reacted with appropriate β‐keto esters in a Pechmann reaction giving the coumarin derivatives 9–11 bearing 4‐nitrobenzylcarbamoyl triggers. These compounds were assessed as potential indicators of nitroreductase activity.