Solvent‐free microwave multicomponent regiospecific synthesis of pyrimido[4,5‐ c ]isoquinolines and evaluation  In Vitro  of their antifungal properties | Zendy

Quiroga Jairo | Zendy; Cisneros Carlos | Zendy; Insuasty Braulio | Zendy; Abonía Rodrigo | Zendy; Nogueras Manuel | Zendy; Sortino Maximiliano | Zendy; Zacchino Susana | Zendy

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Solvent‐free microwave multicomponent regiospecific synthesis of pyrimido[4,5‐ c ]isoquinolines and evaluation In Vitro of their antifungal properties

Author(s) -

Quiroga Jairo,

Cisneros Carlos,

Insuasty Braulio,

Abonía Rodrigo,

Nogueras Manuel,

Sortino Maximiliano,

Zacchino Susana

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430231

Subject(s) - chemistry , antifungal , in vitro , combinatorial chemistry , microwave , organic chemistry , solvent , microwave irradiation , stereochemistry , biochemistry , microbiology and biotechnology , catalysis , physics , quantum mechanics , biology

The free‐solvent multicomponent reaction under microwave irradiation of 6‐aminopyrimidin‐4(3 H )‐ones ( 1 ) with dimedone ( 2 ) and N,N ‐dimethylformamide dimethylacetal yields the pyrimido[4,5‐ c ]isoquinolinones ( 5a‐j ). In this process, the intermediate of cyclization was isolated. The structure of the synthesized compounds was determined on the basis of nmr measurements, especially by 1 H, 1 H‐, 1 H, 13 C COSY, and DEPT. These compounds showed antifungal in vitro activity particularly against dermatophytes.

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