Premium
On the synthesis of 5‐ethyl meldrum's acid
Author(s) -
AkuéGédu Rufine,
ElHafidi Hayate,
Rigo Benoît,
Couturier Daniel
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430217
Subject(s) - meldrum's acid , chemistry , sodium borohydride , acetaldehyde , alkylation , dimer , organic chemistry , medicinal chemistry , catalysis , ethanol
Reductive alkylation of Meldrum's acid with acetaldehyde can give, depending on the experimental conditions, either a new dimer (5‐[3‐(2,2‐dimethyl‐4,6‐dioxo‐1,3‐dioxan‐5‐yl)butyl]‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione) or ethyl Meldrum's acid (2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione). A best way to obtain this latter product is synthesis of 1‐ethoxyethylidene Meldrum's acid from reaction of Meldrum's acid with triethyl orthoacetate, followed by a sodium borohydride reduction.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom