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Synthesis and physicochemical properties of new fluorescent derivatives of cytosine
Author(s) -
Prukala Dorota
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430213
Subject(s) - chemistry , homonuclear molecule , heteronuclear molecule , fluorescence , moiety , substituent , carbon 13 nmr , cytosine , spectral line , nmr spectra database , proton nmr , stereochemistry , nuclear magnetic resonance spectroscopy , organic chemistry , molecule , dna , biochemistry , physics , quantum mechanics , astronomy
ixteen new fluorescent N 4 ‐( E )‐stilbenyloxyalkylcarbonyl‐cytosines 9–16 and N 4 ‐( E )‐stilbenyloxyalkylcarbonyl‐1‐methylcytosines 17–24 have been synthesized. The differences in 1 H and 13 C NMR spectra in two solvents (DMSO and TFA) have been pointed out and discussed. Assignment of the signals in the spectra of the compounds 9–24 in NMR in DMSO‐d 6 solutions has been made the basis of the homonuclear (COSY) and heteronuclear (HETCOR) spectra. The effect of the substituent (Cl, Br, NO 2 ) on the stilbene moiety on the fluorescence spectrum of each compound has been discussed.