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Synthesis and further studies of chemical transformation of the 2‐aryl‐3‐halogenoquinolin‐4(1 H )‐one derivatives
Author(s) -
Mphahlele Malose J.,
Nwamadi Mutshinyalo S.,
Mabeta Peace
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430203
Subject(s) - chemistry , pyridinium , acetic acid , iodine , aryl , chemical transformation , transformation (genetics) , organic chemistry , medicinal chemistry , tribromide , biochemistry , alkyl , gene
The C‐3 brominated and iodinated derivatives were prepared from the corresponding 2‐arylquinolin‐4(1 H )‐ones and their NMe‐4‐oxo derivatives using pyridinium tribromide in acetic acid or iodine‐Na 2 CO 3 mixture in THF. The results of further studies of chemical transformation of the prepared α‐haloenones and preliminary antitumour activity of the 3‐bromo NH‐4‐oxo and NMe‐4‐oxo derivatives are also described.