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A convenient and facile synthesis of pyridine, pyridazine, pyrimido‐[4,5‐ c ]pyridazine, pyrido[3,4‐ c ]pyridazine, 1,6‐naphthyridine and phthalazine derivatives
Author(s) -
El Rady Eman A.,
Barsy Magda A.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430201
Subject(s) - pyridazine , phthalazine , chemistry , acetamide , pyridine , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
Ethyl 2‐arylhydrazono‐3‐butyrates 2 reacted with 2‐cyano‐ N ‐(4‐methylphenyl) acetamide 1a and 2‐cyano‐ N ‐(thiazol‐2‐yl)acetamide 1b to give the pyridinedione, 4 and pyridazine 5 derivatives in 3:1 ratio. The products 4 and 5 have been transformed into different phthalazine, pyrimido[4,5‐ c ]‐pyridazine, pyrido[3,4‐ c ]pyridazine and 1,6‐naphthyridine derivatives. The chemical structures have been confirmed by analytical and spectral analysis.