A convenient and facile synthesis of pyridine, pyridazine, pyrimido‐[4,5‐ c ]pyridazine, pyrido[3,4‐ c ]pyridazine, 1,6‐naphthyridine and phthalazine derivatives | Zendy

El Rady Eman A. | Zendy; Barsy Magda A. | Zendy

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A convenient and facile synthesis of pyridine, pyridazine, pyrimido‐[4,5‐ c ]pyridazine, pyrido[3,4‐ c ]pyridazine, 1,6‐naphthyridine and phthalazine derivatives

Author(s) -

El Rady Eman A.,

Barsy Magda A.

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430201

Subject(s) - pyridazine , phthalazine , chemistry , acetamide , pyridine , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry

Ethyl 2‐arylhydrazono‐3‐butyrates 2 reacted with 2‐cyano‐ N ‐(4‐methylphenyl) acetamide 1a and 2‐cyano‐ N ‐(thiazol‐2‐yl)acetamide 1b to give the pyridinedione, 4 and pyridazine 5 derivatives in 3:1 ratio. The products 4 and 5 have been transformed into different phthalazine, pyrimido[4,5‐ c ]‐pyridazine, pyrido[3,4‐ c ]pyridazine and 1,6‐naphthyridine derivatives. The chemical structures have been confirmed by analytical and spectral analysis.

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