New efficient approach for the synthesis of 2‐alkyl(aryl) substituted 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones | Zendy

Bonacorso Helio G. | Zendy; Righi Fernando J. | Zendy; Rodrigues Isadora R. | Zendy; Cechinel Cleber A. | Zendy; Costa Michelle B. | Zendy; Wastowski Arci D. | Zendy; Martins Marcos A. P. | Zendy; Zanatta Nilo | Zendy

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New efficient approach for the synthesis of 2‐alkyl(aryl) substituted 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones

Author(s) -

Bonacorso Helio G.,

Righi Fernando J.,

Rodrigues Isadora R.,

Cechinel Cleber A.,

Costa Michelle B.,

Wastowski Arci D.,

Martins Marcos A. P.,

Zanatta Nilo

Publication year - 2006

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570430136

Subject(s) - chemistry , alkyl , aryl , yield (engineering) , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy

A new, efficient and easy route for the preparation of a series of 2‐alkyl(aryl) substituted 4‐oxo‐4 H ‐pyrido‐[1,2‐ a ]pyrimidines, where alkyl = CH 3 ; aryl = C 6 H 5 , 4‐FC 6 H 4 , 4‐ClC 6 H 4 , 4‐BrC 6 H 4 , 4‐CH 3 C 6 H 4 , 4‐OCH 3 C 6 H 4 , 4‐NO 2 C 6 H 4 in 45–80 % yield from the reaction of β‐alkoxyvinyl trichloromethyl ketones with 2‐aminopyridine under mild conditions, is then reported.

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