Premium
New efficient approach for the synthesis of 2‐alkyl(aryl) substituted 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones
Author(s) -
Bonacorso Helio G.,
Righi Fernando J.,
Rodrigues Isadora R.,
Cechinel Cleber A.,
Costa Michelle B.,
Wastowski Arci D.,
Martins Marcos A. P.,
Zanatta Nilo
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430136
Subject(s) - chemistry , alkyl , aryl , yield (engineering) , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy
AbstractA new, efficient and easy route for the preparation of a series of 2‐alkyl(aryl) substituted 4‐oxo‐4 H ‐pyrido‐[1,2‐ a ]pyrimidines, where alkyl = CH 3 ; aryl = C 6 H 5 , 4‐FC 6 H 4 , 4‐ClC 6 H 4 , 4‐BrC 6 H 4 , 4‐CH 3 C 6 H 4 , 4‐OCH 3 C 6 H 4 , 4‐NO 2 C 6 H 4 in 45–80 % yield from the reaction of β‐alkoxyvinyl trichloromethyl ketones with 2‐aminopyridine under mild conditions, is then reported.