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Preparation of 6‐azaoxindole (6‐azaindol‐2(3 H )‐one) and substituted derivatives
Author(s) -
Andreassen Einar J.,
Bakke Jan M.
Publication year - 2006
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570430107
Subject(s) - chemistry , pyridine , nitro , group (periodic table) , position (finance) , medicinal chemistry , stereochemistry , organic chemistry , alkyl , finance , economics
A general synthesis of 6‐azaoxindoles, substituted in the 3‐ and 5‐position, has been developed starting from 4‐methoxycarbomethyl‐3‐nitropyridine, via hydrogenation of the nitro group and cyclisation of the resulting 3‐amino‐4‐methoxycarbomethyl‐pyridine.