Premium
Preparation and reactivity of 5‐substituted azepino[3,4‐ b ]indoles
Author(s) -
Montagne C.,
Laurent N.,
Joseph B.,
Mérour J.Y.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420728
Subject(s) - indole test , chemistry , reactivity (psychology) , scope (computer science) , catalysis , combinatorial chemistry , heck reaction , medicinal chemistry , organic chemistry , stereochemistry , palladium , medicine , alternative medicine , pathology , computer science , programming language
Abstract Preparation of the 5‐substituted azepino[3,4‐ b ]indole core structure can be realised through a catalytic Heck reaction. The scope and limitations of this methodology are reported. The reactivity of di‐ tert ‐butyl 5‐ethoxycarbonylmethylene‐1,3,4,5‐tetrahydro‐1‐oxoazepino[3,4‐b]indole‐2,10‐dicarboxylate (1) was investigated in order to prepare the indole analogue of hymenialdisine and derivatives.