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The synthesis of 4‐acylamino‐1,2,4‐triazole derivatives in the reaction of α‐hydroxyacid hydrazidesand orthoesters
Author(s) -
Zieliński W.,
Kudelkoand A.,
Czardybon W.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420720
Subject(s) - chemistry , acetic acid , derivative (finance) , combinatorial chemistry , organic chemistry , economics , financial economics
There action of α‐hydroxyacid hydrazides and orthoesters in ethano1‐acetic acid solution has been studied and aseries of 4‐acylamino‐1,2,4‐triazoles has been obtained as the final products. Some acyclic intermediates: 1‐acyl‐2‐ethoxymethylenehydrazines and N,N′ –bis(methanecarbonylamino) formamidine derivative have been also separated during the process. The structures of products was confirmed by typical spectro‐scopicmethods and X‐ray analysis.