Comparative use of solvent‐free KF‐A1 2 O 3  and K 2 CO 3  in acetone in the synthesis of quinoxaline 1,4‐dioxide derivatives designed as antimalarial drug candidates | Zendy

Lima L. M. | Zendy; Zarranz B. | Zendy; Marin A. | Zendy; Solano B. | Zendy; Vicente E. | Zendy; Silanes S. Perez | Zendy; Aldana I. | Zendy; Monge A. | Zendy

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Comparative use of solvent‐free KF‐A1 2 O 3 and K 2 CO 3 in acetone in the synthesis of quinoxaline 1,4‐dioxide derivatives designed as antimalarial drug candidates

Author(s) -

Lima L. M.,

Zarranz B.,

Marin A.,

Solano B.,

Vicente E.,

Silanes S. Perez,

Aldana I.,

Monge A.

Publication year - 2005

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570420718

Subject(s) - quinoxaline , chemistry , acetone , solvent , organic solvent , organic chemistry , chemical engineering , engineering

In this paper we describe two new basic conditions for the synthesis of quinoxaline 1,4‐dioxide derivatives in moderate to good yields. These conditions, exemplified by the use of K 2 C0 3 in acetone or KF/A1 2 0 3 in the absence of an organic solvent, were reproducible and applicable to the synthesis of 2‐(carboethoxy)‐3‐phenylquinoxaline 1,4‐dioxide derivatives substituted in position 4 with electron‐donating or electron‐withdrawing groups.

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