Premium
Comparative use of solvent‐free KF‐A1 2 O 3 and K 2 CO 3 in acetone in the synthesis of quinoxaline 1,4‐dioxide derivatives designed as antimalarial drug candidates
Author(s) -
Lima L. M.,
Zarranz B.,
Marin A.,
Solano B.,
Vicente E.,
Silanes S. Perez,
Aldana I.,
Monge A.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420718
Subject(s) - quinoxaline , chemistry , acetone , solvent , organic solvent , organic chemistry , chemical engineering , engineering
Abstract In this paper we describe two new basic conditions for the synthesis of quinoxaline 1,4‐dioxide derivatives in moderate to good yields. These conditions, exemplified by the use of K 2 C0 3 in acetone or KF/A1 2 0 3 in the absence of an organic solvent, were reproducible and applicable to the synthesis of 2‐(carboethoxy)‐3‐phenylquinoxaline 1,4‐dioxide derivatives substituted in position 4 with electron‐donating or electron‐withdrawing groups.