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A facile synthesis of substituted pyridines and pyrazolo[3,4‐ b ]pyridines
Author(s) -
Kidwai M.,
Thakur R.,
Saxena S.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420622
Subject(s) - chemistry , yield (engineering) , microwave irradiation , pyridine , solvent , microwave , organic chemistry , reaction conditions , reaction rate , combinatorial chemistry , catalysis , quantum mechanics , metallurgy , materials science , physics
A facile, solvent free, ecofriendly approach for the synthesis of 2‐amino‐3(ethylcarboxy)‐4,6‐disubsti‐tuted pyridine 4 and pyrazolo[3,4‐ b ]pyridines 6 is herein described employing neat reaction conditions under microwave irradiation. This solventless methodology is environmentally benign as it completely eliminates the use of solvent from the reaction procedure. The observed reaction rate enhancement and high yield of products are due to the neat reaction conditions coupled with microwaves (MWs).