Synthesis and antimycobacterial activity of alkyl 1‐heteroaryl‐1 H ‐1,2,3‐triazole‐4‐carboxylates | Zendy

Japelj Boštjan | Zendy; Rečnik Simon | Zendy; Čebašek Petra | Zendy; Stanovnik Branko | Zendy; Svete Jurij | Zendy

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Synthesis and antimycobacterial activity of alkyl 1‐heteroaryl‐1 H ‐1,2,3‐triazole‐4‐carboxylates

Author(s) -

Japelj Boštjan,

Rečnik Simon,

Čebašek Petra,

Stanovnik Branko,

Svete Jurij

Publication year - 2005

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570420620

Subject(s) - antimycobacterial , chemistry , alkyl , carboxylate , triazole , 1,2,4 triazole , stereochemistry , medicinal chemistry , 1,2,3 triazole , organic chemistry , mycobacterium tuberculosis , medicine , tuberculosis , pathology

A series of alkyl l‐heteroaryl‐1 H ‐1,2,3‐triazole‐4‐carboxylates 6a‐u were synthesised in four steps from methyl ( Z )‐2‐benzyloxycarbonylarmino‐3‐(dimethylamino)prop‐2‐enoate ( 1 ) and heterocyclic amines 2a‐s. Triazoles 6a‐o were tested against antimycobacterial activity. For the most active compound, n ‐pentyl 1‐(6‐phenylpyridazin‐3‐yl)‐1 H ‐1,2,3‐triazole‐4‐carboxylate ( 6n ), minimum inhibitory concentration 3.13 μg/ml was determined.

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