Premium
Synthesis and antimycobacterial activity of alkyl 1‐heteroaryl‐1 H ‐1,2,3‐triazole‐4‐carboxylates
Author(s) -
Japelj Boštjan,
Rečnik Simon,
Čebašek Petra,
Stanovnik Branko,
Svete Jurij
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420620
Subject(s) - antimycobacterial , chemistry , alkyl , carboxylate , triazole , 1,2,4 triazole , stereochemistry , medicinal chemistry , 1,2,3 triazole , organic chemistry , mycobacterium tuberculosis , medicine , tuberculosis , pathology
A series of alkyl l‐heteroaryl‐1 H ‐1,2,3‐triazole‐4‐carboxylates 6a‐u were synthesised in four steps from methyl ( Z )‐2‐benzyloxycarbonylarmino‐3‐(dimethylamino)prop‐2‐enoate ( 1 ) and heterocyclic amines 2a‐s. Triazoles 6a‐o were tested against antimycobacterial activity. For the most active compound, n ‐pentyl 1‐(6‐phenylpyridazin‐3‐yl)‐1 H ‐1,2,3‐triazole‐4‐carboxylate ( 6n ), minimum inhibitory concentration 3.13 μg/ml was determined.