Preparation of 2‐amino‐5‐methyl‐7 H ‐1,3,4‐thiadiazolo[3,2‐α]pyrimidin‐7‐ones

2‐Amino substituted 7 H ‐1,3,4‐thiadiazolo[3,2‐α]pyrimidin‐7‐ones 11a‐e were prepared by the reaction of 2‐bromo‐5‐amino‐1,3,4‐thiadiazole ( 1b ) and diketene ( 8 ), subsequent cyclocondensation ( 9b → 3b ) and displacement of the bromo substituents by the reaction with primary or secondary amines ( 3b → 11a‐e ). The hydrogen atom 6‐H in the heterobicycle 3b is replaced by a Cl or Br atom in the transformation of 3b → 14a,b. The 2‐bromo‐6‐chloro compound 14a reacts chemoselectively in the 2‐position with dimethylamine ( 14a → 15 ). The structure elucidations are based on one‐ and two‐dimensional NMR techniques including a heteronuclear NOE measurement.