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Synthesis of chiral building blocks for cephalostatin analogues
Author(s) -
Yunus Uzma,
Iqbal Rashid,
Winterfeldt Ekkhard
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420607
Subject(s) - ketone , chemistry , mass spectrometry , carbon 13 nmr , proton nmr , resolution (logic) , stereochemistry , organic chemistry , combinatorial chemistry , chromatography , artificial intelligence , computer science
The present paper describes the synthesis of 5‐azido‐6‐ketones (14) and 6‐hydroxy‐5‐ketone (20) from Hajos Wiechert ketone as chiral building blocks for cephalostatin analogues. The synthesis of symmetric cephalostatin analogue from 6‐hydroxy‐5‐ketone has also been reported. The characterization of the each synthesized compounds was carried out by IR, 1 H‐NMR, 13 C‐NMR and High resolution Mass Spectrometry.