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Rapid synthesis of 2,5‐disubtituted 1,3,4‐thiadiazoles under microwave irradiation
Author(s) -
Lebrini Mounim,
Bentiss Fouad,
Lagrenée Michel
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420538
Subject(s) - chemistry , microwave irradiation , thiadiazoles , hydrazine (antidepressant) , elemental analysis , hydrogen sulfide , sulfur , ethanol , condensation , microwave , organic chemistry , proton nmr , condensation reaction , nuclear chemistry , sulfide , medicinal chemistry , catalysis , chromatography , physics , quantum mechanics , thermodynamics
The one pot, three‐components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5‐disubstituted 1,3,4‐thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in‐situ . The structure of the compounds was confirmed by 1 H, 13 C NMR, MS and elemental analysis.